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Current UK law generally restricts all injectable products to POM status

Most research protocols use daily or every-other-day dosing, with administration timing synchronized to the active metabolic phase of the model (early light cycle for nocturnal rodents)

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Patients with mild to moderate renal impairment generally do not require dose adjustment, but closer monitoring may be warranted, particularly for signs of gastrointestinal adverse effects that could lead to dehydration and worsening renal function