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GLP-1 Receptor Agonists and Carcinogenicity Risk: From Liraglutide to Oral Small Molecules Abstract GLP-1 receptor agonists have evolved from injectable peptides such as liraglutide and semaglutide to novel oral small molecules including orforglipron and elecoglipron, expanding treatment options for diabetes and obesity
doi:10.1655/0733-1347(2003)017[0111:HUBGMT]2.0.CO;2
Nature
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HGH (Somatropin): FDA-approved for specific indications: pediatric growth hormone deficiency, adult GHD, Turner syndrome, HIV/AIDS-related wasting, short bowel syndrome Prescription-only medication requiring physician monitoring Illegal to distribute for off-label purposes including anti-aging (per the 1990 Anabolic Steroids Control Act amendments) Brand names include Genotropin, Norditropin, Humatrope, Saizen CJC-1295 and Ipamorelin: Neither is FDA-approved for any therapeutic indication Available as research compounds for laboratory use only (RUO Research Use Only) Not scheduled substances, but not approved for human therapeutic use Ipamorelin has undergone Phase I/II clinical trials (Johansen et al., 1999) but development did not progress to approval For a deeper look at Ipamorelin's regulatory history, see our Ipamorelin FDA approval status guide
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