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These improvements in senescence markers and the inflammatory microenvironment underscore FOXO4-DRIs potential to rejuvenate testicular function by clearing senescent cells and mitigating their detrimental effects

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However, these cardiovascular applications require particularly careful consideration given the potential risks associated with promoting angiogenesis in patients who may have undiagnosed malignancies or other conditions where angiogenesis promotion could be detrimental

A deficiency of NAD+ may disrupt the circadian rhythm and result in effects such as daytime sleepiness, restless sleep, hormonal imbalances, and mood alterations, among others

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