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Remarkably the level of glucose-stimulated H 2 O 2 production in beta cells was shown to reach a similar magnitude, although with slower kinetics, compared with rat neutrophils (a cell type recognised for its ability to generate large amounts of ROS) [23]
Clin Cancer Res 19: 58355841 Osthus RC, Shim H, Kim S, Li Q, Reddy R, Mukherjee M, Xu Y, Wonsey D, Lee LA, Dang CV (2000) Deregulation of glucose transporter 1 and glycolytic gene expression by cMyc
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This highlights the potential impact of effective treatment for obesity in improving long term outcomes, especially when combined with other lifestyle interventions such as diet and exercise changes
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