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10.2741/999 66 UllahA.PirzadaM.JahanS.UllahH.TuriN.UllahW.et al (2018)
Bile acids as key modulators of the brain-gut-microbiota axis in Alzheimer's disease
Although all unimolecular triple agonists in phase 2 trials for obesity are GLP1/GIP/GCG triple agonists, there is an ongoing phase 2 clinical trial of bioglutide, an oral insulin-like-growth factor-1 (IGF-1)/GLP-1/GIP/GCG quadruple agonist (NCT06564753) for individuals with obesity, which is also being trialled in combination with tirzepatide (NCT06643728)
Activation of PARP-1 also leads to decreased NADPH levels because this particular PARP inhibits the glycolytic enzyme, hexokinase
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