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Scrocchi et al., 1996), this mechanism propelled the development of GLP-1 receptor agonists (GLP-1RAs), initially approved for diabetes (2005) and later for obesity (2014) (Jastreboff and Kushner, 2023)
Cardiovascular outcomes in trials of new antidiabetic drug classes: a network meta-analysis
Kuloglu M, Ustundag B, Atmaca M, Canatan H, Tezcan AE, Cinkilinc N (2002) Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder
This becomes even more important since many off-label users get less monitoring than diabetic patients
Figure 1 The second study assessed the capacity of divalproex sodium to reduce the incidence of CPS when administered as the sole AED
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