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At a later stage, MET is predominantly pre-synaptic, reflecting a dynamic regulation of MET expression depending on the post-natal age of the examined mice ( FIGURE 2 The pMET protein levels peak at P7P14 in the neocortex, a period corresponding to synaptogenesis and dendritic outgrowth, and are downregulated during the 3rd post-natal week, between P14 and P17, when pruning and functional synapse maturation occur ( Rhesus monkey) ( Beyond Neurotrophic Functions: HGF-MET Play a Role in Synaptogenesis and Neuroplasticity Circumstantial evidence indicates that MET is implicated in the synapse formation

Wegovy delays gastric emptying and commonly causes nausea, vomiting, and gastrointestinal discomfort, particularly during dose escalation

A retrospective observational study performed by Silveira et al

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