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trial, subjects receiving weekly doses of 30 to 60 mcg/kg (roughly 2,000 to 4,000 mcg for an 80 kg adult) showed sustained IGF-1 elevation with no serious adverse events over the study period (Teichman et al., J Clin Endocrinol Metab 2006)

Analysis of the predicted structure of IR35_C4 docked with R -THIQ and the nicotinamide adenine dinucleotide phosphate (NADP) cofactor suggested that the N177E substitution hydrogen bonds with the ligand amine, while the M184W residue stacks with the ligand phenyl group to promote the formation of the R -enantiomer (Fig