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[18] FDA identified limitations in characterization data, potential immunogenicity concerns for injectable use, limited information for proposed routes, lack of established effectiveness for obesity, and insufficient long-term safety information
This model is also satisfying from an evolutionary biology perspective in which GLP-1 and GIP do not have redundant functions in the brain, but rather fit into complimentary niches
1988 Aug 29;238(2):343-346
Current Opinion in Neurobiology, 78 , 102668
A BMI above 35 is recognized as class II obesity, while a BMI of 40 or above is class III obesity
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