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Vitamin B12 is a water-soluble nutrient essential for red blood cell production, DNA synthesis, and energy metabolism

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For example, NAD+-dependent enzymes include the sirtuins (SIRT1-7), a family of protein deacetylases involved in gene expression, stress responses, and metabolic regulation, as well as poly(ADP-ribose) polymerases (PARPs) that assist in DNA repair

Butyrate appears also involved in reducing the immune response to LPS, helping T-cell differentiations, and decrease IL-6 and IL-12 secretion