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and aids in the synthesis of carnitine, which is essential for fat oxidation

This requirement can be difficult to manage for patients with busy or unpredictable schedules

The details about the advantages and disadvantages of each route are present in Supplementary 4

Liraglutide (Saxenda) NICE Technology Appraisal TA664 recommends liraglutide as an option for managing overweight and obesity in adults with a BMI of 35 kg/m or more (or 3034.9 kg/m in certain circumstances) alongside at least one weight-related comorbidity, within a specialist weight management service

NICE guidance recommends initial treatment with hydroxocobalamin 1mg intramuscularly three times weekly for two weeks, followed by maintenance therapy