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4.3 Epilepsy and uremia 4.3.1 Association of uremia with seizures Patients with end-stage renal disease who underwent dialysis had a greater prevalence of epilepsy (8.8%), and the risk of death in patients diagnosed with epilepsy was 1.11 times greater than that in patients without epilepsy (108)

Zinc homeostasis and signaling in health and diseases: zinc signaling

References Arranz L, et al

(1) Metformin upregulates the small hetero-dimer partner through the AMPK signaling pathway, which interacts directly with the cAMP-response-element-binding factor (CREB) to block the recruitment of CREB to CREB-regulated transcription co-activator 2 (CRTC2), downregulating the expression of gluconeogenic genes (4)

even without exercise