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The practical implication is straightforward

Folate helps maintain healthy DNA and keep cancer-promoting genes turned off. Animal studies, however, suggest that exceptionally high amounts or intervention after cancer cells have formed might promote development of cancer

However, it is important to be careful with the initial dosing of probenecid (and was also the case for sulfinpyrazone) due to the fact that at the initial low circulating levels of the drug it actually acts to inhibit urate excretion resulting in transient increases in serum urate

This dosage did not cause negative health effects except for minor skin yellowing