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By inhibiting NNMT, 5-Amino-1MQ increases cellular SAM and NAD+ levels, enhances NAD+ salvage pathway flux, activates SIRT-1, boosts oxidative phosphorylation (OXPHOS), and influences cellular energy homeostasis and epigenetic modifications
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For example, ALK fusions in NSCLC represent actionable alterations, with multiple ALK inhibitors demonstrating efficacy in ALK-positive tumors
Stomach upset Mild side effects include nausea or stomach pain
Common symptoms of anemia include fatigue, weakness, and shortness of breath
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