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Massons trichrome staining additionally indicated that PQQ-treatment protected against TAC-induced myocardial fibrosis in these animals (Figure 1I)

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Although the mechanisms through which astrocytes maintain BBB integrity are not fully understood, there are several proposed astrocytic-derived soluble factors that may induce vital aspects of the BBB including interleukin-6 (IL-6), glial cell line-derived neurotrophic factor (GDNF), basic fibroblast growth factor (bFGF), fibroblast growth factor 2 (FGF-2), angiopoetin 1 (ANG1), and TGF [45, 46]

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Although cells benefit from low or moderate ROS levels, high ROS impose irreversible oxidative damage and so efficient ROS removal is necessary to maintain homeostasis 21,106 and controlled cellular activation