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Viruses (2019)

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Orlistat may be considered when centrally acting AOMs are contraindicated, though long-term efficacy is limited

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Key highlights: Demonstrated sustained improvements across symptomatic, clinical, endoscopic, histologic, and quality-of-life endpoints Benefits seen even in ~27% of patients who had failed prior biologics or advanced therapies Long-term safety profile consistent with prior findings no new safety signals Among patients continuing from blinded maintenance to the open-label extension, 12% reported serious adverse events, 7% discontinued due to adverse events Approved for UC and Crohns disease in 44 countries These results (from the LUCENT-3 extension) were shared at UEG Week 2025 in Berlin and mark a significant milestone in the pursuit of durable, steroid-free remission for IBD patients