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2021 (Nature Reviews Mol Cell Biol) document age-related NAD+ decline and the biology that drives clinical interest
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To enhance mitochondrial activity (which metformin does through AMPK activation) But what about all the research saying that metformin inhibits exercises benefits
Preliminary data from a phase II study of EV in 11 heavily-treated refractory mCRPC patients demonstrated an acceptable safety profile and promising efficacy with a 64% overall response rate: no grade 5 TRAEs were reported, 5/11 patients achieved PSA decline 50%, 3/4 patients had an objective response, 4/7 had declines in CTCs, and 2/11 had stable disease for 6 months 184
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