what's the average weight loss on semaglutide Real-world data show weekly effective for at 3, 6 months Surgery Bests Lifestyle Changes, GLP-1

Side effects, surgery, pregnancy planning, or simply running out of refills can pause your semaglutide use

Samson SL, Vellanki P, Blonde L, et al

Available from: Clayton AH, Goldstein I, Kim NN, et al

| Parameter | Orforglipron (oral pill) | Retatrutide (injectable peptide) | | --- | --- | --- | | Molecular class | Non-peptide small molecule | Peptide (amino acid chain) | | Receptor profile | GLP-1 (single target) | GIP + GLP-1 + glucagon (triple) | | Administration | Oral, tablet | Subcutaneous injection | | Interval | Once daily | Once weekly | | Half-life | Short (daily dosing) | approx

It binds to GLP-1 receptors but also acts on the gastric inhibitory polypeptide (GIP) receptor