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Side effects, surgery, pregnancy planning, or simply running out of refills can pause your semaglutide use
Samson SL, Vellanki P, Blonde L, et al
Available from: Clayton AH, Goldstein I, Kim NN, et al
| Parameter | Orforglipron (oral pill) | Retatrutide (injectable peptide) | | --- | --- | --- | | Molecular class | Non-peptide small molecule | Peptide (amino acid chain) | | Receptor profile | GLP-1 (single target) | GIP + GLP-1 + glucagon (triple) | | Administration | Oral, tablet | Subcutaneous injection | | Interval | Once daily | Once weekly | | Half-life | Short (daily dosing) | approx
It binds to GLP-1 receptors but also acts on the gastric inhibitory polypeptide (GIP) receptor
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