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JT: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing original draft, Writing review and editing

During tumorigenesis, abnormal hypermethylation of the cytosine in CpG islands and hypomethylation of the whole genome result in genome instability and alterations in gene expression profile, including silencing of tumor suppressor genes, endogenous retro-elements, and tumor antigens, and activation of oncogenes (Liang and Weisenberger, 2017

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Finally, the clinical studies summarized used collagen (bovine or animal sources such as fish, collagen peptides, and hydrolyzed collagen, where some test materials were commercially available products while others used multiple custom formulations), which are noted in the brief descriptions above

Accessed July 26, 2021