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Though evidence has identified apoptosis as the predominant mode of RGC death in models of several optic neuropathies, strategies targeting it have proved unsatisfactory, with research suggesting that RGCs rescued by Caspase inhibition only achieved partial neuroprotection (93)

While animal studies cannot definitively rule out human cancer concerns, the consistent absence of tumors or pre-cancerous changes across multiple species, dosing regimens, and administration routes carries meaningful weight

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