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474 These molecules are thought to induce various intracellular damage-associated processes, such as Golgi dispersion, lysosomal rupture, and mitochondrial dysfunction, facilitating the assembly of the NLRP3 inflammasome

This isn't exhaustive, of course, but it gives a good overview of what we're talking about when we discuss optimal conditions

We also know that low levels of NAD+ have some quite harmful effects on our bodies, such as: Suffocating our bodies cells Increasing risk of sunburns and skin cancer Associated with fatigue Quickens Aging Worsens weight gain and metabolic syndrome Decreases Cellular Antioxidants May worsen Cardiovascular Diseases May contribute to Multiple Sclerosis Can Impair Brain Function Harms Immune Balance/Function Increases Inflammation Decreases metabolism along with Thyroid Hormones Many of the harmful symptoms of low NAD+ can be likened to the symptoms of aging itself

10.1016/j.ejpb.2008.06.008 Eur

If this is the case, your doctor will likely advise against taking GLP-1 medications