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Tumor-associated macrophages (TAMs), important immunosuppressive cells in the microenvironment, are able to activate the Gli2/IGF-2/ERK1/2 signaling axis to promote TGF- secretion and thus mediate the migration, invasion and EMT of hepatocellular carcinoma cells (Huh-7 cells) (73)
Moore does worry, however, that $50 per month co-pays, while much less expensive than previous prices for the drugs, may still be out of reach for some of the neediest Americans
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