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Despite the limitations like small sample size, the recruitment limited to two stages of DKD, the assessment of only an acute effect of the drug our study found a short-term hypertensive effect of GLP-1R agonist liraglutide in diabetic kidney disease that seems to be related to impaired renal sodium excretion

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Notably, the results demonstrated that UA exerts its effects by downregulating microtubule-associated proteins 1A/1B light chain 3B and Lysosomal-associated membrane protein 1 expression, without significantly altering PINK1 and Parkin protein levels (36)