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The peptide accelerates early collagen organization and stimulates expression of the EGR-1 gene along with its repressor NAB2, creating a regulatory feedback loop that prevents excessive fibrosis while promoting organized tissue remodeling

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The sigma class of cGSTs is also related to these processes, particularly the detoxification of xenobiotics and peroxides due to glutathione-dependent peroxidase activity, as well as immunomodulation of the immune response through the synthesis of prostaglandins [1214]

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The SURMOUNT-5 head-to-head trial showed tirzepatide produced 47% more weight loss than semaglutide (20.2% vs 13.7%)