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Although not thought to be directly influenced by obesity, lipoprotein (a) is an independent risk factor for cardiovascular disease that is determined by genetics
Achieving site-specific transcranial drug delivery to closed-skull TBI patients may be more difficult than the authors imply: the subarachnoid space filled with circulating cerebrospinal fluid (CSF) is about 3-4 mm deep in humans (3), more than an order of magnitude deeper than in mice, permitting CSF to quickly remove drug molecules from a targeted cortical site
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They also clarified in another clinical study that supplements with glycine (1.33 mmol/kg/day) and N-acetylcysteine (0.81 mmol/kg/day) for 24 weeks corrected erythrocyte-GSH deficiency and alleviated oxidative stress and mitochondrial dysfunction in elderly individuals [110]
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