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Most studies have relatively short follow-up periods (typically 35 years), and breast cancer can have a long latency period

The 2.4 mg weekly maintenance dose is where the phase 3 monotherapy trials showed the strongest results, with an average body weight reduction of 11.8% over 68 weeks

An increase in ROS accelerates tumor cell death, while GSH, as a key component in redox homeostasis, plays a crucial role in scavenging ROS and neutralizing exogenous metabolites in tumor cells [15]

Less common side effects include flushing, headache, or nausea

Deeper concerns like pigmentation and fine lines take eight to twelve weeks of consistent use to show significant change