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Problems such as SIBO, altered intestinal microbiota, and delayed gastric emptying have added to the difficulties of oral therapy in PD, often culminating in commonly observed motor fluctuations such as delayed on or early-morning off sometimes associated with severe non-motor symptoms as well
"Sometimes people feel nauseous or experience an upset stomach, diarrhea or constipation," Dr
The localized Administration of vitamin B12 can directly target affected nerves
PMID: 18061177
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