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the results were never released
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It was clinically approved by both the Food and Drug Administration (FDA) and the European Medicine Agency (EMA) in 2014 for the treatment of relapsing-remitting multiple sclerosis (MS), showing a significant efficacy over 2 years versus placebo and a favorable benefit-risk profile in two phase-III clinical trials, although with several adverse effects such as nausea, diarrhea, abdominal pain and leukopenia in some patients [282, 283]
The peptide selectively induces p53 nuclear exclusion and apoptosis in hydrogen peroxide-induced senescent Leydig cells in vitro, confirming direct cellular targeting
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