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When oxygen and transporter capacity are sufficient, it serves as an oxidative fuel and signaling molecule for neurons, through astrocyte-neuron lactate shuttling [11, 12]
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Interestingly, DMF was found to induce cysteine biosynthesis 26 , elevate cellular GSH levels 27 , and present an NRF2-independent effect through posttranslational protein succinylation 28,29
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