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Malignant Peripheral Nerve Sheath Tumor (MPNST) is an extremely rare tumor (1/100,000) that represents up to 10% of sarcomas, divided into those related to Neurofibromatosis type 1 (NF1), which corresponds to 50% of cases, and sporadic ones.1,2 The most widely accepted hypothesis today is that NF1-related MPNST arises from a neurofibroma that undergoes multiple genetic and phenotypic alterations until transforming into a malignant lesion

Fever A low-grade fever could stem from a minor illness, but if it happens alongside nausea, vomiting, abdominal pain, or fatigue, it may be tied to pancreatitis or an infection

This higher dose did produce more gastrointestinal side effects, but the additional weight loss was statistically significant

Most patients begin seeing meaningful weight loss within the first few weeks, especially when paired with lifestyle changes

Monitoring and Communication Patients should report new or worsening symptoms for evaluation and guidance