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[4] [5] Patients experiencing symptoms potentially related to cortisol abnormalitiessuch as unexplained weight gain (particularly central obesity), persistent fatigue, muscle weakness, easy bruising, or mood changesshould undergo appropriate evaluation before attributing these to metabolic syndrome alone

Because these medications affect the way the body digests food, they can also cause disruptive gastrointestinal side effects, including a loss of appetite, stomach upset, nausea, vomiting, or diarrhea