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It has been hypothesized that a smaller number of cytosolic GST genes in the European honey bee ( Aphis mellifera ) than in other insect species might be associated with pesticide sensitivity and reduction in vitality [72]
Some of the BCRP substrates are also effectively effluxed by P-gp
This move is a clear signal that the future of metabolic therapeutics lies in integrated, multi-pathway approaches that treat the whole system, not just one organ
For example, INT-777 and MN6, TGR5 selective agonists, stimulated GLP-1 secretion and improved insulin sensitivity in diet-induced obesity (DIO) mice [180, 181]
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