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For patients with severe obesity and metabolic disease, they save lives
Importantly, we also demonstrate that GLP-1 and its derivatives directly antagonize TRPV1 channels in a mode-selective manner that can offer pain relief without the adverse thermoregulatory side effects commonly associated with current TRPV1 inhibitors
Gadde KM, Martin CK, Berthoud HR, Heymsfield SB (2018) Obesity: pathophysiology and management
Psychopharmacology 103 : 187196
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