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Bariatric surgery represents the most effective intervention for severe obesity, producing average weight loss of 25-30% of total body weight with durable results extending beyond 10 years

The approval of injectable semaglutide for adolescents aged 12 and older in 2022 established a precedent for GLP-1-based weight management in younger patients, and an oral option could substantially change the treatment calculus for this population

The four types of MS each present different challenges for peptide-based interventions

Differences in cohort, duration, and titration make a precise cross-trial advantage unreliable

While they usually manifest in a specific organ consistently, they can affect other systems