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the principal pharmacological-interaction consideration is co-administration with exogenous melatonin or other pineal-axis-modifying agents, where the proposed mechanism overlaps and pharmacodynamic addition rather than subtraction would be expected

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When standard, unformulated glutathione is ingested, the highly acidic environment of the stomach (which has a pH of less than 1.5) and the aggressive digestive enzymes (peptidases) in the small intestine rapidly cleave the tripeptide into its three constituent amino acids