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Excess B12 from oral supplements is poorly absorbed at high doses (the body absorbs roughly 1 to 2% of a 1,000 mcg oral dose) and the remainder is excreted in urine
27 Decreased expression of xCT leads to an increase in the rate of sulphur transfer from homocysteine to cysteine (through the trans-sulphuration branch of the methionine cycle), supporting the pivotal role of xCT in cyst(e)ine transport and cysteine provision
A., Moussa, Z., Mughal, E
Satoh and Lipton 2017
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