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Midorikawa S, Sanada H, Hashimoto S, and Watanabe T (2000)

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Document clinical contraindication to semaglutide: Persistent nausea or vomiting preventing dose escalation beyond initial doses, a documented thyroid concern (e.g., personal or family history of MEN 2 or medullary thyroid carcinoma), or another clinically documented intolerance can serve as the basis for the exception request

For systemic research, certain contraindications exist, such as pregnancy, breastfeeding, active cancer, or conditions like Wilsons disease (a genetic disorder causing copper accumulation)

Nishida, T