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Whilst glucagon raises blood glucose levels, GLP-1 helps lower them, demonstrating the complex regulatory mechanisms governing glucose homeostasis in the human body

Stanford Medicine endocrinologist Sun Kim, MD, MS, and bariatric and minimally invasive surgeon Dan Azagury, MD, FACS, explain how these medications work, who may or may not benefit, the potential benefits and risks, and why they're not a one-size-fits-all solution

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It is likely to be prescribed alongside lifestyle changes such as dietary improvements and increased physical activity

From 2.4% to 17.6% in Four Years A Truveta analysis of real-world data from January 2021 to September 2025 found that semaglutide or tirzepatide prescribing among women with PCOS rose from 2.4% in 2021 to 17.6% in 2025 more than a seven-fold increase