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Mendelian randomization analysis suggests a potential genetic link between increased opioid use and the risk of major depressive disorder (MDD) and anxiety-related disorders 62

When to choose an endocrinologist: If you have type 2 diabetes with complex management needs, complications from diabetes, other hormonal conditions, or if your primary care doctor recommends specialist management

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In practice, these differences are usually minor and fall within the range of individual variation, but they add a layer of uncertainty that pharmaceutical products do not have

Pregnancy and severe renal impairment have also been standard exclusion criteria across major trials