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Based on previous randomized studies evaluating the effects of GLP-1 receptor agonists on smoking-related outcomes and nicotine dependence, the standard deviation of FTND scores was estimated to be approximately 2 points, and a 2-point reduction was considered clinically meaningful ( Blinding and randomization After obtaining informed consent and completing baseline assessments, participants will be randomly assigned in a 1:1 ratio to the GLP-1RA group or the control group

Because compounded versions are not FDA-approved, they are typically not covered by insurance

Patients should expect to talk about weight history, appetite cues, cravings, meal timing, exercise limitations, prior medication response, family history, sleep, stress, and medical risks

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doi: 10.1136/gutjnl-2012-304353 75 DickerD