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This post-transcriptional regulatory mechanism modulates mRNA stability and translation of key iron-handling genes
iPSC clones and introduction of the doxycycline-inducible NGN2 expression vector We used an iPSC clone obtained from a DS patient and a trisomy-corrected isogenic clone generated from the trisomy clone as previously described 25
The one-carbon metabolic pathway is tightly regulated by intracellular levels of metabolites and cofactors, such as high intracellular SAM levels that activate CBS and inhibit MTHFR, thus shifting hcy levels from transmethylation toward transsulfuration reactions (Finkelstein, 2007)
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Down Syndrome: Searching for the Genetic Culprits. DMM Disease Models and Mechanisms
