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Appetite changes within days to weeks

There is a strong recommendation not to combine DPP-4 inhibitors with GLP-1 receptor agonists, and DPP-4 inhibitor therapy should be discontinued when treatment is escalated with an injectable therapy at later stages with a GLP-1 receptor agonist (7072)

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An oral tablet formulation (semaglutide Rybelsus) is also available, taken once daily on an empty stomach