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M., Yoon, S.-H

Its easy to think of testosterone as strictly a male hormone, but women need small amounts of it, too

Its effects require intact amylin receptor signaling, as demonstrated in receptor knockout models where weight loss is abolished, and structural studies show unique conformational dynamics at these receptors compared to native amylin or other analogs

It accelerates the breakdown of existing fat stores and prevents new fat from forming, regardless of caloric intake

Nonetheless, striking similarities have been described concerning the endocrine profile between centenarians and subjects after a calorie-restricted diet