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The authors use this rationale cautiously to reconcile the mismatch between improved cognition and reduced brain volume, stating A clearance and subsequent shifts in cerebrospinal fluid may therefore have also partially explained their findings

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The Food and Drug Administration regulates therapeutic peptides separately from research reagents

(2011) 6:e22623

The HPA axis normally triggers cortisol release during stress, but chronic activation leads to elevated baseline cortisol, which is linked to weight gain, inflammation, and metabolic dysfunction