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This accumulation effect is why results do not appear instantly
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Early inflammatory responses include the migration of neutrophils and macrophages, production of pro-inflammatory cytokines and chemokines such as TNF-, IL-1, and IL-6 at different stages of HF (157), mediation of myocardial cell necrosis and exacerbation of adverse cardiac remodeling (158), making the targeted inhibition of neutrophil-derived pro-inflammatory factors an active area of research for treating HF
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