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470,478,482,483,484 GLP-1RAs in the digestive system Treatment with GLP-1RAs can alleviate insulin signaling by reducing the phosphorylation of Akt protein (Decreased Akt-P) and activating Protein Kinase C- (PKC-)

Degradation is driven by hydrolysis and oxidation

Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness

Furthermore, mice made diabetic by streptozotocin (STZ) administration, but genetically deficient for the GcgR, display normal glucose tolerance [49]