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Ultimately, molecule 38 (Figure 6) was determined to be the most potent agent, with an IC 50 of 41.17 nM (111)

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Across clinical trials and real-world settings, weight loss remained modest, relapse rates after discontinuation were high, and treatment was often fragmented, lacking integration into interdisciplinary care models

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Glp1r RT-PCR in primary cultures of mouse spinal cord astrocytes Primary cultures of astrocytes were established from the spinal cord of 3-day-old C57Bl/6 J male mice following standard procedures 66