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The other redox system with similar roles is the thioredoxin system, comprised of thioredoxin and thioredoxin reductase ( Because DNA is an add-on to RNA biosynthesis, deoxyribonucleotides can only be synthesized via the reduction of ribonucleotides by RNR, a process which is unsustainable without the participation of one or both of the thioredoxin and glutaredoxin systems

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The bigger safety concern is not the dose, its the source