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For many individuals, oral B12 supplements are ineffective due to such underlying conditions as: Pernicious anemia : People with this condition lack intrinsic factor, a protein required for B12 absorption in the small intestine

Oral Pathology & Medicine

However, response times can vary based on the severity of the deficiency and individual health factors

Garca-Minguilln et al., Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine, Genes Nutr., vol