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One intriguing theory suggests that colonizing microglia are guided by a fractalkine gradient, which is sensed through the microglial fractalkine receptor, CX3CR1 (Mondo et al., 2020), which helps guide microglia along the developing vasculature

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This triggers the MAPK cascade, such that Ras-GTP activates Raf [also called MAPK kinase kinase (MAPKKK)], which in turn activates MEK1/2 [MAPK kinase (MAPKK)]